Argireline® study

ARGIRELINE

Argireline®

The first peptide against expression wrinkles.

The first hexapeptide analogous to the N-terminal end of SNAP-25 competes with this protein for a position in the SNARE complex. Argireline® peptide is an alternative to Botulinum Toxin, which acts topically on the same mechanism of wrinkle formation but in a completely different way.

One of the most characteristic features of aging skin is the appearance of wrinkles on the face. It is a natural phenomenon produced by the passage of time and identified by biochemical, histological and physiological changes, which are accentuated by environmental exposure, and other secondary factors such as the force of gravity or the constant repetition of movements caused by muscle contraction Of facial expression. Muscles contract by receiving neurotransmitters released by vesicles.

Argireline® peptide is analogous to the N-terminal end of SNAP-25 and competes with the natural protein for a position in the SNARE complex. If the SNARE complex is slightly destabilized, the vesicles can not anchor and release the neurotransmitters efficiently and therefore the muscle contraction is attenuated, preventing the formation of wrinkles.

IN VITRO EFFICACY

Modulation of glutamate release in a cell culture of neurons
Inhibition of glutamate secretion by depolarized neuronal cells is a validated cellular assay to evaluate compounds potentially inhibitory to neuronal exocytosis. Cell cultures of untreated neurons were used as negative controls.

Argireline® peptide has a high inhibitory potential for glutamate release. Inhibition of glutamate release at mM concentrations is a clear indicator of the potent anti-wrinkle activity of this hexapeptide.

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IN VITRO ACTION MECHANISM

Muscle contraction
The neurotransmitter involved in muscle contraction is the acetylcholine that is released by a vesicle to the synapse. The SNARE protein complex consists of three proteins: VAMP, Syntaxin and SNAP-25 and is essential for the release of the neurotransmitter to the synapse and to mediate the latter stages of exocytosis. This complex is like a cellular hook that captures the vesicles and brings them closer to the membrane so that its fusion can occur.

Botulinum Toxin A
Botulinum toxin A paralyzes the muscle by selectively blocking the release of acetylcholine at the neuromuscular junction. BoNT-A cleaves the SNAP-25 protein irreversibly, preventing the formation of the SNARE complex. The nervous signal can not be transmitted, so the muscle can not be contracted and paralyzed.

Argireline® peptide
Argireline® peptide is an analogue to the N-terminal end of SNAP-25 and competes with the natural protein for a position in the SNARE complex, destabilizing its formation without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters. As a result, muscle contraction is attenuated and the muscle relaxes.

LIVE EFFICIENCY

Effect on the volume and depth of wrinkles
A panel of 24 volunteers applied a cream with 2% Argireline® peptide solution in the middle of the face, especially in the area of crow’s feet, and a placebo cream on the other half, twice a day for 7 days . Skin photographs were obtained and the topography was evaluated quantitatively. Volume was reduced by -20.6% and length by -1519% (statistically significant).

Determination of effectiveness against skin wrinkles
10 volunteers were given an emulsion with 10% argireline peptide solution around the eyes, twice a day for 30 days. Silicone molds were obtained before the test and after 15 and 30 days. The molds were analyzed by confocal laser microscopy. The wrinkles were reduced by -17% after 15 days.

Information provided courtesy of Lipotec S.A.U.

MUJER-ARGIRELINE-2
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PRODUCTS CONTAINING ARGIRELINE:

ASPOLVIT BTX Beauty drops: Innovative anti-aging capsules. They reduce the lines of expression, especially the contour of the eyes and the lips. Its texture is suitable for all types of skins.

Dermatologically proven.
No parabens or coloring.

Composition: Argireline® Peptide NF.

How to use: Open the capsule, making a half turn. Apply the contents of the capsule on the face with a gentle massage until completely absorbed. Avoid direct eye contact.

Presentation: 10/30 topical capsules.

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